Commercialization of technology is one of the importants element of innovation process and there are several difficulties to do that. Evaluating and pricing of know –how is one of the most complicated activities in commercialization process. The complexity of technology and know-how pricing has caused difficulties for research technology institutes (RTIs) leading them to use heuristic method for pricing. On the other hand, they are eager to use scientific methods for pricing in commercialization process. In this paper, a model was developed to systematically evaluate know-how and then to price the technology based on experience and heuristics method. Then the model was tested with the real cases in the Research Institute of Petroleum Industry (RIPI)(Iran).